The study compared the tissue tropism of two H5N1 strains in mice: 2004 H5N1 strain from a fatal human case. 2024 bovine H5N1 strain cur...
The study compared the tissue tropism of two H5N1 strains in mice:
2004 H5N1 strain from a fatal human case.
2024 bovine H5N1 strain currently circulating.
2004 H5N1 Strain, Replication largely confined to the respiratory tract.
"Limited" replication in the central nervous system (CNS).
2024 Bovine H5N1 Strain: Successfully replicated in the respiratory tract and various brain regions.
Significance of Findings:
Highlights a broader tissue tropism of the 2024 bovine strain, particularly its ability to infect the CNS.
Suggests potential changes in the pathogenicity and host adaptation of the 2024 bovine H5N1 strain compared to the 2004 strain.
Neurotropism is the ability of a pathogen to invade and survive in the nervous system
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